HPE announced the first HPE ProLiant Gen13 servers powered by 6th Generation AMD EPYC processors for enterprise AI workloads.
HPE has announced the first four models of its HPE ProLiant Gen13 Servers, powered by 6th Generation AMD EPYC Server processors. The new systems expand compute, memory, and I/O capabilities to accelerate agentic AI and inference, analytics, virtualization, simulation, and modeling, while strengthening security, simplifying operations, and improving reliability across distributed IT environments.
As AI systems evolve from generating insights to autonomous action, trust becomes essential for scale. McKinsey's 2026 AI Trust Maturity Survey found that nearly two-thirds of respondents cited security and risk concerns as the top barrier to fully scaling agentic AI. HPE ProLiant Gen13 addresses these concerns with a trusted infrastructure foundation combining HPE iLO 8 innovations for automatic protection, infrastructure trust, and post-quantum readiness, alongside enhanced visibility and control from HPE Compute Ops Management.
"Organizations need to turn their investments in agentic AI and inference into business value without adding operational complexity or risk," said Krista Satterthwaite, senior vice president and general manager of Compute at HPE. "For these workloads, HPE ProLiant Gen13 brings together optimized performance, built-in automatic security, intelligent operations, and proven reliability. It gives customers a trusted foundation to modernize and innovate today and adapt as their requirements evolve."
"AI is moving into the applications and operations that run the enterprise, fundamentally changing what organizations demand from their infrastructure," said Dan McNamara, senior vice president and general manager of Compute and Enterprise AI at AMD. "Across generations of AMD EPYC CPUs and HPE ProLiant servers, our teams have worked side by side to turn advances in processor and system design into practical value for customers. With 6th Gen AMD EPYC processors and HPE ProLiant Gen13, we are delivering the performance, efficiency and flexibility enterprises need to scale AI while modernizing the critical workloads their businesses depend on."
HPE ProLiant Gen13 reinforces the company's leadership in enterprise compute by introducing servers that simplify the path to innovation and provide the secure foundation needed for the AI era. Combining HPE engineering with 6th Gen AMD EPYC Server processors enables higher core density, memory bandwidth, and I/O capacity.
The HPE ProLiant DL585a Gen13 Server is a high-density platform supporting up to eight double-wide PCIe GPUs, two 6th Gen AMD EPYC Server processors, and PCIe Gen6 connectivity. The server maximizes GPU utilization, token throughput, and PCIe bandwidth for demanding workloads including AI inference, virtualization, retrieval-augmented generation (RAG) model fine-tuning, analytics, and agentic AI.
The HPE ProLiant DL525 Gen13 Server is a compact, performance-optimized 1U single-socket system powered by one 6th Gen AMD EPYC Server processor with up to 256 cores. High bandwidth 16-channel memory with support for DDR5 and MRDIMM, along with PCIe Gen6 connectivity, makes the system ideal for extremely high data throughput workloads such as fraud detection, market-data processing, risk and pricing models, electronic design automation (EDA), simulation, and AI inference.
For large-scale, compute-intensive applications, HPE is introducing the HPE ProLiant XD245 Server and HPE ProLiant XD285 Server—two OCP-compliant systems designed to maximize compute performance within a smaller footprint. The XD245 uses a 1OU four-node direct liquid-cooled design powered by up to eight 6th Gen AMD EPYC Server processors. The XD285 uses a 2OU two-node air-cooled design, extending the architecture to a broader range of data center environments. Both systems provide the capacity, bandwidth, and infrastructure flexibility needed for CPU-intensive workloads including computer-aided engineering (CAE), weather and climate modeling, scientific research, and financial modeling.
HPE ProLiant Gen13 will expand beyond these initial systems, offering additional choices for mainstream enterprise, edge, virtualization, software-defined infrastructure, database, and AI workloads.
HPE ProLiant Gen13 combines automatic security from HPE Integrated Lights-Out 8 (iLO 8) with enhanced HPE Compute Ops Management capabilities to protect data and system integrity while simplifying deployment and lifecycle operations. Industry-first features include automatic self-encrypting drive (Auto-SED) server capabilities that protect data at rest from first boot without added configuration, external key managers, or manual activation; multi-person authorization (MPA) requiring two authorized users to approve high-impact actions including key provisioning and secure erase, reducing the risk of single-user error or misuse; expanded post-quantum cryptography (PQC) readiness extending beyond firmware to protect server communication paths from emerging threats; and enterprise-grade component verification built upon HPE's Silicon Root of Trust, validating the authenticity and integrity of critical server components throughout the server lifecycle.
New HPE Compute Ops Management capabilities help customers operate HPE ProLiant Gen13 infrastructure with greater efficiency and resiliency through low-touch onboarding and near real-time power capacity insights. Organizations using HPE Compute Ops Management spent 50% less time managing servers and generated 209% ROI.
Each new generation of HPE ProLiant undergoes more than 1,000 tests and 10,000 hours of validation to deliver consistent performance, availability, and resilience. This includes advanced stress and corner-case testing that push systems beyond published operating limits. Reliability is the leading HPE ProLiant customer purchase driver for four consecutive years, with 81% citing reliable performance as a key differentiator from other server vendors and twice-fast support resolution. HPE Tech Care Service further strengthens resiliency by delivering up to 97% less unplanned downtime, helping customers prevent, identify, and resolve issues as infrastructure needs change.
The HPE ProLiant DL525 Gen13 server will be available later in 2026. The HPE ProLiant DL585a Gen13 server will be available in early 2027. The HPE ProLiant XD245 and XD285 Servers will be available in 2027. HPE ProLiant Gen13 Servers are available through HPE Financial Services' 90/9 Advantage program, which offers no payments for 90 days, followed by nine months at 1% per month, helping organizations move forward with critical technology investments outside budget cycles.