HPE launches four ProLiant Gen13 server configurations powered by AMD EPYC Venice processors for AI workloads.

Hewlett Packard Enterprise has unveiled four new ProLiant Gen13 servers powered by AMD's 6th Generation EPYC processors, codenamed Venice, designed to handle demanding AI workloads while minimizing heat output and security risks.

The headline specification is density. The Gen13 lineup supports up to 256 cores per socket with high-core-count EPYC chips and up to 600W of thermal design power (TDP) per socket—the amount of heat a chip is built to produce and shed under load. Memory capacity received a significant upgrade, with support for up to 16 memory channels of DDR5 running at speeds up to 8,000 MT/s. The systems also support PCIe 6.0, the latest interface generation connecting processors to GPUs, storage and networking cards.

HPE is shipping four distinct configurations tailored to different workloads. The ProLiant DL525 Gen13 targets CPU-based AI inference—the phase where trained models answer questions or make predictions. The ProLiant DL585a Gen13 is accelerator-optimized and supports up to eight double-wide GPUs. The XD245 and XD285 round out the lineup, focusing on advanced cooling for CPU-intensive HPC and AI workloads.

HPE positions the lineup for hybrid workloads spanning agentic AI, inference, analytics and modeling. Agentic AI refers to systems that can autonomously take actions and complete multistep tasks rather than simply responding to prompts.

Security has received upgrades through a new version of HPE iLO 8, which adds automatic self-encrypting drive support—enabling data encryption on storage without manual configuration—alongside readiness for post-quantum cryptography, encryption methods designed to withstand future quantum computers.

The company says it applied lessons learned from its work on exascale supercomputers Frontier and El Capitan, systems capable of performing at least a quintillion calculations per second. The launch follows AMD's earlier announcements around its EPYC 9006 series, bringing that silicon into production systems aimed at enterprise buyers.