EQUINIX INC files 424B5: prospectus (424B)

The information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not soliciting an offer to buy these securities in any jurisdiction where the offer or sale is not permitted.

Subject to completion, dated July 30, 2026

Preliminary Prospectus Supplement (To Prospectus Dated February 13, 2026)

Equinix, Inc.

Equinix Europe 2 Financing Corporation LLC

Unconditionally Guaranteed by Equinix, Inc.

Equinix, Inc., a Delaware corporation (the “Parent”), is offering $ aggregate principal amount of % Senior Notes due 20 (the “20 Notes”), $ aggregate principal amount of % Senior Notes due 20 (the “20 Notes”) and $ aggregate principal amount of % Senior Notes due 20 (the “20 Notes”). Equinix Europe 2 Financing Corporation LLC (“Europe 2 Finco”, and together with the Parent, the “Issuers” and, each, an “Issuer”), a Delaware limited liability company that is an indirect, wholly-owned subsidiary of the Parent, is offering $ aggregate principal amount of % Senior Notes due 20 (the “20 Notes” and together with the 20 Notes, the 20 Notes and the 20 Notes, the “notes”).

Interest will accrue on the 20 Notes from , 2026 and will be payable semi-annually on and of each year, commencing , 2027, on the 20 Notes from , 2026 and will be payable semi-annually on and of each year, commencing , 2027, on the 20 Notes from , 2026 and will be payable semi-annually on and of each year, commencing , 2027 and on the 20 Notes from , 2026 and will be payable semi-annually on and of each year, commencing , 2027. The Parent or Europe 2 Finco, as the case may be, may redeem the notes at its option in whole or in part at any time or from time to time at the redemption prices described under “Description of the 20 , 20 and 20 Notes — Optional Redemption,” or “Description of the 20 Notes — Optional Redemption,” which include accrued and unpaid interest thereon, if any, to, but not including, the applicable redemption date.

Depending on when such notes are redeemed, a make-whole premium may or may not be payable in respect of any such redemptions.

The 20 Notes will be fully and unconditionally guaranteed on an unsecured basis by the Parent.

Upon a change of control triggering event, the relevant Issuer will be required to make an offer to purchase each holder’s notes, at a purchase price equal to 101% of the aggregate principal amount thereof plus accrued and unpaid interest, if any, to but not including, the date of purchase.

The notes will not be listed on any securities exchange or automated dealer quotation system. Currently there is no public market for the notes.

Investing in the notes involves risks. See “Risk Factors” beginning on page S-9 of this prospectus supplement, as well as the risks described in “Risk Factors” in our most recent Quarterly Report on Form 10-Q, which is incorporated by reference into this prospectus supplement and the accompanying prospectus.

Underwriting discount % $ % $ % $ % $

Proceeds, before expenses, to Equinix (1) % $ % $ % $ % $

Plus accrued and unpaid interest, if any, from , 2026.

The Issuers expect to deliver the notes in book-entry form through the facilities of The Depository Trust Company (“DTC”) against payment in New York, New York on or about , 2026, which is the fifth business day following the date of this prospectus supplement (this settlement cycle is referred to as “T+5”). Purchasers of the notes should note that trading of the notes may be affected by the settlement date.

The following is a brief summary of certain terms of this offering. For a more complete description of the terms of the notes offered hereby, see “Description of the 20 , 20 and 20 Notes” and “Description of the 20 Notes” in this prospectus supplement and the section titled “Description of Debt Securities” in the accompanying prospectus.

Issuers Equinix, Inc., a Delaware corporation, Issuer of the 20 , 20 and 20 Notes;

Equinix Europe 2 Financing Corporation LLC, a Delaware limited liability company, Issuer of the 20 Notes.

Guarantor

The 20 Notes will be unconditionally guaranteed by Equinix, Inc., a Delaware corporation.

Notes Offered $ aggregate principal amount of notes, consisting of:

aggregate principal amount of the 20 Notes;

The completion of the offering of the 20 , 20 and 20 Notes and the completion of the offering of the 20 Notes are not conditioned on each other.

Maturity Dates 20 Notes: , 20 .

20 Notes: , 20 .

20 Notes: , 20 .

20 Notes: , 20 .

Interest The 20 Notes will bear interest from , 2026 at the rate of % per annum.

The 20 Notes will bear interest from , 2026 at the rate of % per annum.

Interest Payment Dates 20 Notes: and of each year, beginning on , 2027.

20 Notes: and of each year, beginning on , 2027.

Ranking

The 20 , 20 and 20 Notes will be the Parent’s general senior obligations. Your right to payment under these notes will be:

effectively subordinated to all of the Parent’s existing and future secured indebtedness;

structurally subordinated to all existing and future indebtedness and other liabilities (including trade payables) of any of the Parent’s subsidiaries;

As of June 30, 2026, Equinix, Inc. had approximately $9.6 billion of outstanding indebtedness (inclusive of finance lease liabilities).

The 20 Notes will be Europe 2 Finco’s general senior obligations. Your right to payment under these notes will be:

effectively subordinated to any of Europe 2 Finco’s existing and future secured indebtedness;

structurally subordinated to any existing and future indebtedness and other liabilities (including trade payables) of any of Europe 2 Finco’s subsidiaries, if any;

As of June 30, 2026, Europe 2 Finco had no subsidiaries and $6.4 billion of outstanding indebtedness (excluding trade payables and intercompany items and liabilities of a type not required to be reflected on the balance sheet of Equinix, Inc.’s subsidiaries in accordance with U.S. generally accepted accounting principles, or GAAP).

Guarantee

The 20 Notes will be fully and unconditionally guaranteed on an unsecured basis by Equinix, Inc. Equinix, Inc.’s obligations under the guarantee will be:

effectively subordinated to all of Equinix, Inc.’s existing and future secured indebtedness;

structurally subordinated to all of the existing and future indebtedness and other liabilities (including trade payables) of other subsidiaries of Equinix, Inc.;

As of June 30, 2026, after giving effect to the entry by Equinix, Inc. into the 2026 Revolving Facility but without giving effect to this offering:

Equinix, Inc. had total consolidated indebtedness of

approximately $22.0 billion, approximately $15 million of which represented secured indebtedness, which excludes approximately $2.3 billion of finance lease liabilities;