ADVANCED MICRO DEVICES INC files 424B5: prospectus (424B)

File No. 333-298288 PROSPECTUS SUPPLEMENT (To prospectus dated August 13, 2026)

We are offering $1,250,000,000 aggregate principal amount of our 4.600% Senior Notes due 2029 (the “2029 notes”), $1,500,000,000 aggregate principal amount of our 5.000% Senior Notes due 2031 (the “2031 notes”), $1,000,000,000 aggregate principal amount of our 5.250% Senior Notes due 2033 (the “2033 notes”) and $1,000,000,000 aggregate principal amount of our

5.500% Senior Notes due 2036 (the “2036 notes” and, together with the 2029 notes, the 2031 notes and the 2033 notes, the “notes”).

The 2029 notes will bear interest at the rate of 4.600% per year and mature on August 17, 2029. Interest on the 2029 notes will accrue from

August 17, 2026 and will be payable semi-annually in arrears on February 17 and August 17 of each year, beginning on February 17, 2027.

The 2031 notes will bear interest at the rate of 5.000% per year and mature on August 17, 2031. Interest on the 2031 notes will accrue from

The 2033 notes will bear interest at the rate of 5.250% per year and mature on August 17, 2033. Interest on the 2033 notes will accrue from

The 2036 notes will bear interest at the rate of 5.500% per year and mature on August 17, 2036. Interest on the 2036 notes will accrue from

The notes will be our unsecured senior obligations and will be equal in right of payment with all of our other existing and future unsecured senior indebtedness. We may redeem the notes in whole or in part at any time prior to their maturity at the redemption prices described in this prospectus supplement.

The notes will not be guaranteed by any of our subsidiaries. The obligations to make payments of principal and interest on the notes are solely our obligations. Therefore, the notes will be structurally subordinated to all indebtedness and other obligations of our subsidiaries.

The 2029 notes, the 2031 notes, the 2033 notes and the 2036 notes are each a new issue of securities with no established trading market. We do not intend to apply for the listing or trading of the notes of either series on any securities exchange or trading facility or for inclusion of the notes of either series in any automated quotation system.

Investing in the notes involves risks. See the “ Risk Factors ” section beginning on page S-12 of this prospectus supplement.

(1) Plus accrued interest from August 17, 2026, if settlement occurs after that date.

(2) See “Underwriting” for additional information regarding underwriting compensation.

Neither the U.S. Securities and Exchange Commission nor any state securities commission has approved or disapproved of these

The underwriters expect to deliver the notes in book-entry form through the facilities of The Depository Trust Company for the accounts of its participants, including Clearstream Banking S.A. and Euroclear Bank SA/NV, as operator of the Euroclear System, against payment in New York, New York on or about August 17, 2026.

Joint Book-Running Managers

Barclays BofA Securities Citigroup J.P. Morgan

Morgan Stanley Wells Fargo Securities

BNP PARIBAS BNY Capital Markets Credit Agricole CIB Goldman Sachs & Co. LLC

HSBC Loop Capital Markets PNC Capital Markets LLC SMBC Nikko

Standard Chartered Bank TD Securities

Prospectus Supplement dated August 13, 2026

PROSPECTUS SUPPLEMENT Page

About This Prospectus Supplement S-1

Where You Can Find More Information; Incorporation by Reference S-2

Trademarks and Copyrights S-4

Cautionary Note Regarding Forward-Looking Statements S-5

The summary below describes the principal terms of the notes. Certain of the terms and conditions described below are subject to important limitations and exceptions. The “Description of Debt Securities” section of the accompanying prospectus, as supplemented by the “Description of Notes” section of this prospectus supplement, contains a more detailed description of the terms and conditions of the notes. As used in this section, “we,” “our,” and “us” refer to Advanced Micro Devices, Inc. and not to its consolidated subsidiaries.

Issuer Advanced Micro Devices, Inc.

Notes Offered Hereby $1,250,000,000 aggregate principal amount of 4.600% Senior Notes due 2029 (the “2029 notes”).

$1,500,000,000 aggregate principal amount of 5.000% Senior Notes due 2031 (the “2031 notes”).

$1,000,000,000 aggregate principal amount of 5.250% Senior Notes due 2033 (the “2033 notes”).

$1,000,000,000 aggregate principal amount of 5.500% Senior Notes due 2036 (the “2036 notes” and, together with the 2029 notes, the 2031 notes and the 2033 notes, the “notes”).

The 2029 notes, the 2031 notes, the 2033 notes and the 2036 notes will each constitute a separate series of our debt securities under the indenture pursuant to which the notes will be issued.

Interest Payment Dates 2029 notes: February 17 and August 17 of each year, beginning February 17, 2027.

Ranking The notes will be:

• equal in right of payment with all our existing and future senior unsecured indebtedness, including our existing senior notes and any future borrowings under the Revolving Credit Agreement;

• senior in right of payment to our future indebtedness, if any, that are by their terms expressly subordinated or junior in right of payment to the notes;

• structurally subordinated in right of payment to all of our subsidiaries’ existing and future indebtedness and other obligations (including trade payables); and

• effectively subordinated to our future secured indebtedness, if any, to the extent of the value of the assets securing such indebtedness.

As of June 27, 2026, on an as adjusted basis after giving effect to this offering:

• we would have had approximately $8.0 billion of consolidated indebtedness and approximately $14.0 billion of consolidated other liabilities outstanding (excluding intercompany liabilities and liabilities of a type not required to be recorded on a balance sheet in accordance with GAAP), including indebtedness under the notes and our existing senior notes, none of which was guaranteed by any of our subsidiaries and none of which was secured by liens on our assets;

• we would have been able to borrow up to $5.0 billion (less outstanding letters of credit) under the Revolving Credit Agreement; and

• our subsidiaries, none of which are guarantors of the notes, would have had approximately $750 million of indebtedness and approximately $11.9 billion of other liabilities outstanding (excluding intercompany liabilities and liabilities of a type not required to be recorded on a balance sheet in accordance with GAAP), all of which would be structurally senior to the notes.