EQUINIX INC files 424B5: prospectus (424B)

The information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not soliciting an offer to buy these securities in any jurisdiction where the offer or sale is not permitted.

Subject to completion, dated April 30, 2026

Preliminary Prospectus Supplement (To Prospectus Dated February 13, 2026)

Equinix Canada Financing Ltd.

C$ % Senior Notes due 20 C$ % Senior Notes due 20

Unconditionally Guaranteed by Equinix, Inc.

Equinix Canada Financing Ltd. (the “Issuer”), an indirect, wholly-owned subsidiary of Equinix, Inc., is offering C$ aggregate principal amount of % Senior Notes due 20 (the “20 notes”) and C$ aggregate principal amount of % Senior Notes due 20 (the “20 notes” and, together with the 20 notes, the “notes”). Interest will accrue on each series of notes from May , 2026. Interest will be payable semi-annually on and of each year, commencing , 2026 for the 20 notes and on and of each year, commencing , 2026 for the 20 notes. The initial interest payment will be C$ per C$1,000 of principal amount for the 20 notes and C$ per C$1,000 of principal amount for the 20 notes.

The Issuer may redeem either series of notes in whole or in part at any time or from time to time at the applicable redemption price described under “Description of Notes — Optional Redemption,” which include accrued and unpaid interest thereon, if any, to, but not including, the applicable redemption date. In addition, in the event of certain developments affecting taxation, we may redeem each series of notes, in whole but not in part, at our option, at a redemption price equal to 100% of their principal amount, plus accrued and unpaid interest, if any, thereon to, but excluding, the applicable redemption date. See the section titled “Description of Notes — Redemption upon a Tax Event.” Depending on when such notes are redeemed, a make-whole premium may or may not be payable in respect of any such redemptions.

The notes will be fully and unconditionally guaranteed on an unsecured basis by Equinix, Inc., a Delaware corporation.

The notes will be the Issuer’s unsecured senior obligations and will rank equal in right of payment to all of the Issuer’s existing and future unsecured and unsubordinated indebtedness and structurally subordinated to all of the liabilities of the Issuer’s subsidiaries, if any. In addition, Equinix, Inc.’s obligations under the guarantees will rank equally with all of its other unsecured and unsubordinated indebtedness and will be effectively subordinated to all of the existing and future secured indebtedness of Equinix, Inc. and structurally subordinated to all of the indebtedness and liabilities of other subsidiaries of Equinix, Inc. Upon a change of control triggering event, the Issuer will be required to make an offer to purchase each holder’s notes at a purchase price equal to 101% of the aggregate principal amount thereof plus accrued and unpaid interest, if any, to but not including, the date of purchase.

The notes will not be listed on any securities exchange or automated dealer quotation system. Currently there is no public market for the notes.

Investing in the notes involves risks. See “Risk Factors” beginning on page S-12 of this prospectus supplement, as well as the risks described in “Risk Factors” in our most recent Quarterly Report on Form 10-Q, which is incorporated by reference into this prospectus supplement and the accompanying prospectus.

The following is a brief summary of certain terms of this offering. For a more complete description of the terms of the notes offered hereby, see “Description of Notes” in this prospectus supplement and the section titled “Description of Debt Securities” in the accompanying prospectus.

Issuer Equinix Canada Financing Ltd., an Ontario corporation.

Guarantor Equinix, Inc., a Delaware corporation.

Notes Offered

C$ aggregate principal amount of the 20 notes; and C$ aggregate principal amount of the 20 notes.

Maturity Date , 20 for the 20 notes and , 20 for the 20 notes.

Interest

The 20 notes will bear interest from May , 2026 at the rate of % per annum and the 20 notes will bear interest from May , 2026 at the rate of % per annum.

Interest Payment Dates and of each year, beginning on , 2026 for the 20 notes and and of each year, beginning on , 2026 for the 20 notes.

Day Count Convention

Actual/Actual (Canadian Compound Method). For a full semi-annual interest period, interest will be computed on the basis of a 360-day year of twelve 30-day months. For an interest period that is not a full semi-annual interest period, interest will be computed on the basis of a 365-day year and the actual number of days in such interest period.

Currency of Payment All payments of interest and principal for the notes, including any payments made upon any redemption, will be made in Canadian dollars.

To the extent Canadian dollars are unavailable to us due to the imposition of exchange controls or other circumstances beyond our control, then all payments in respect of the applicable series of notes will be made in U.S. dollars until Canadian dollars are again available to us. See “Currency Conversion” in this prospectus supplement.

Ranking

The notes will be the Issuer’s general senior obligations. Your right to payment under these notes will be:

effectively subordinated to any of the Issuer’s future secured indebtedness;

structurally subordinated to any future indebtedness and other liabilities (including trade payables) of any of the Issuer’s subsidiaries, if any;

As of March 31, 2026, the Issuer had no subsidiaries and $494 million of outstanding indebtedness (excluding trade payables and intercompany items and liabilities of a type not required to be reflected on the balance sheet of Equinix, Inc.’s

subsidiaries in accordance with U.S. generally accepted accounting principles, or GAAP).

Guarantee

The notes will be fully and unconditionally guaranteed on an unsecured basis by Equinix, Inc. Equinix, Inc.’s obligations under the guarantees will be:

effectively subordinated to all of Equinix, Inc.’s existing and future secured indebtedness;

structurally subordinated to all of the existing and future indebtedness and other liabilities (including trade payables) of other subsidiaries of Equinix, Inc.;

As of March 31, 2026, without giving effect to this offering:

Equinix, Inc. had total consolidated indebtedness of approximately $21.9 billion, approximately $17 million of which represented secured indebtedness, which excludes approximately $2.3 billion of finance lease liabilities;